Correspondence to https://doi.org/10.1097/RLU.0000000000002732 (2019). The authors declare no conflict of interest. Current paradigm of response to therapy in Hodgkins lymphoma. Epub 2013 Nov 15. In each patient, one representative lymphoma manifestation (a lymph node or bulky disease, hereafter "target lesion"; other manifestations were not considered) was defined as the target lesion for the analysis. Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models. Verloh, N.; Einspieler, I.; Utpatel, K.; Menhart, K.; Brunner, S.; Hofheinz, F.; van den Hoff, J.; Wiggermann, P.; Evert, M.; Stroszczynski, C.; et al. Lymphoma spreads to extranodal sites by direct invasion or by hematogenous spread to the spleen, liver, lungs, or bone marrow.14,15 High-grade lymphomas can present as oncologic emergencies because of the structural compression from the enlarging tumor, including superior vena cava syndrome, malignant epidural spinal cord compression, or malignant pericardial effusion.16 Paraneoplastic syndromes are rare with lymphoma, occurring as paraneoplastic cerebellar degeneration in Hodgkin lymphoma and as dermatomyositis and polymyositis in Hodgkin and non-Hodgkin lymphomas.17, The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry.3 Although fine-needle aspiration and core needle biopsy are often part of the initial evaluation of any adenopathy, neither will provide adequate tissue for the diagnosis of lymphoma because of the need to verify Hodgkin lymphoma via the presence of Reed-Sternberg cells.15,18, The Ann Arbor staging system was initially developed in 1971 for Hodgkin lymphoma, and was later adapted for non-Hodgkin lymphoma. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. PET data from scanner B were reconstructed iteratively with Bayesian penalized likelihood reconstruction (GE Q.Clear) with a penalization factor of 450, which included time of flight analysis and point spread function modeling21. People without Breast Implant-Associated Anaplastic Large Cell Lymphoma. Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. We tested all features scanner-wise for their diagnostic performance to evaluate if and which similarities exist between both datasets (single feature diagnostic performance). Article Purpose: https://doi.org/10.1016/j.ymeth.2020.06.020 (2021). Barrington, S.F. Their interim, end of treatment, and follow-up PET scans were retrospectively visually analyzed and assigned DS by three nuclear medicine physicians. Leuk. AJR Am J Roentgenol 2019;212:456-60. ; Krasin, M.J.; Kogos, P.G. Lancet Oncol. Jerusalem G, Beguin Y, Fassotte MF, Najjar F, Paulus P, Rigo P. Cheson BD, Horning SJ, Coiffier B, Shipp MA, Fisher RI, Connors JM. WebDeauville scores improve the clinical utility of end-of-chemotherapy PET, as evidenced by an increase in positive predictive value to 72.7% from 44.4% on the basis of report alone. Zwanenburg, A. et al. Hodgkin lymphoma (HL) is one of the most common cancer types in young adults with the incidence peaking in people in their 20s. Cite this article. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. We also searched the Agency for Healthcare Research and Quality evidence reports, UpToDate, the Cochrane database, Essential Evidence Plus, the National Comprehensive Cancer Network, and the Surveillance, Epidemiology, and End Results database. Dr. Julian Rogasch is participant in the BIH-Charit Digital Clinician Scientist Program funded by the Charit Universittsmedizin Berlin, the Berlin Institute of Health, and the German Research Foundation (DFG). However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. Chemotherapy treatment plans differ between the main subtypes of lymphoma. Find support for a specific problem in the support section of our website. This articledid not receive any funding. The new staging system incorporates two symptom-based classifications: A (absence of symptoms) and B (presence of fever, weight loss, and night sweats) for Hodgkin lymphoma. https://doi.org/10.1080/10428194.2020.1786555 (2020). Progression-free survival (PFS) was well stratified according to a visual assessment of interim PET/CT using 5-PS (p < 0.001). Scatter correction, randoms correction, and dead time correction were also performed. Provided by the Springer Nature SharedIt content-sharing initiative. ; All authors have read and agreed to the published version of the manuscript. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Your email address will not be published. FOIA Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good Comparison of commonly used SUV metrics for differentiation between paediatric tumours. In the meantime, to ensure continued support, we are displaying the site without styles Mikhaeel NG, Hutchings M, Fields PA, O'Doherty MJ, Timothy AR. Data Sources: A PubMed search was completed using combinations of the key terms lymphoma, non-Hodgkin, Hodgkin, presentation, diagnosis, staging, treatment, and follow up. 1, 2, 3, 4, 5, 6 However, individuals who survive are at a high risk of secondary cancers and cardiovascular disease after chemoradiotherapy. Lambin, P. et al. Faudemer, J. et al. J.Nucl. ; Zucca, E.; Lister, T.A. Role of imaging in the staging and response assessment of lymphoma: Consensus of the International Conference on Malignant Lymphomas Imaging Working Group. HHS Vulnerability Disclosure, Help Hello I want to change document wide default font. A median activity of 250MBq 18F-FDG (interquartile range (IQR), 233262MBq) was administered intravenously. You are accessing a machine-readable page. Lymphoma 50, 12571260. ; Silver, B.; Marcus, K.C. Reproducibility of radiomics is a general concern, restraining the implementation of radiomic signatures into clinical routine37. Sci Rep 12, 20008 (2022). https://doi.org/10.1158/0008-5472.CAN-17-0339 (2017). PubMed Central Conclusions: Our study confirmed that DS is a useful tool to aid in reporting F-18 FDG PET-CT in the management of HL with good positive and negative predictive values. Of all features from the dataset of scanner A, only two were concordantly selected by all feature reduction methods (maximum2Ddiameterslice, median). pROC: An open-source package for R and S+ to analyze and compare ROC curves. Interestingly, even in NECT images, the feature median that ultimately describes the density of a lymphoma manifestation differentiated between DS4-positive and DS4-negative lesions, thereby showing constantly higher values in DS4-positive manifestations (numerical results of the radiomics analysis are provided in the supplementary Table S3; S3a for scanner A and S3b for scanner B). ; methodology, F.I. https://doi.org/10.5152/dir.2015.15220 (2016). Methods 188, 2029. SUV max reduction (SUV max) and tumor/liver ratio (TLr) are promising tools for response assessment in lymphoma.We determined the optimal cutoff values for SUV max and TLr and Classical Hodgkin lymphoma is one of the most curable paediatric and adult cancers, with survival rates exceeding 90%. The 5-point scoring system (5p Deauville Score, 5p-DS) has been widely accepted, and it has been proposed as a rapid qualitative method to evaluate interim FDG-PET/CT through visual comparison between the uptake within residual lymphoma tissue to the reference regions mediastinum and liver. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. Lancet. This site needs JavaScript to work properly. Ibrahim, F.; Gabelloni, M.; Faggioni, L.; Padma, S.; Visakh, A.R. Leuk Lymphoma 2009;50:1257-60. WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. A full list of features with an ICC below 0.8 is given in the supplementary Table S5. WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. PET scan followed after a median uptake time of 68min (IQR, 63.576.5min). Reproducibility of radiomics for deciphering tumor phenotype with imaging. 1 None of the 8 patients with a Deauville score of 3 at PET-2 scanning relapsed, but 1 of the 3 patients with a Deauville score of 4 eventually relapsed. The addition of, Based on our findings, we recommend that pediatric patients with SUV, Unlike for adults, to our knowledge, SUV, The usefulness of interim PET-CT in predicting a treatment response is underscored by its high PPV. Article https://doi.org/10.1007/s00259-014-2715-9 (2014). 2023, 13, 445.https:// versus the Deauville score (DS) for assessing the chemotherapy response in pediatric HL patients J. Pers. Excluding the patients who had a Deauville score of 3, the 2-year PFS for PET-positive patients with a Deauville score of 4 to 5 was still excellent at 75%. Bhakta, N.; Liu, Q.; Yeo, F.; Baassiri, M.; Ehrhardt, M.J.; Srivastava, D.K. Would you like email updates of new search results? Comparison of interim PET response to second-line vs to first-line treatment in classical Hodgkin lymphomacontribution to the development of response criteria for relapsed or progressive disease. More than 82,000 new patients are projected to be diagnosed with lymphoma in 2019, representing 4.7% of all new cancer cases in the United States. Long-term cause specific mortality of patients treated for Hodgkins disease. The feature median showed a high sensitivity for DS4+ manifestations on both scanners (scanner A: 0.91, scanner B: 0.85). PubMed 44, e559e565. Systemic symptoms of fever, unexplained weight loss, and night sweats occur in a subset of patients with more advanced disease. They found that CT density correlated with 18F-FDG uptake, 68Ga-DOTATOC uptake, and 68Ga-PSMA uptake and suggested a Hounsfield scale to differentiate benign from malignant lymph nodes. Rep. 11, 23812. https://doi.org/10.1038/s41598-021-03278-9 (2021). Our results should be verified in larger, more consistent patient populations examined on CT scanners from additional vendors to affirm median as a robust feature across scanners and should be validated externally according to Shahzadi44 supporting clinical applicability. Ann Surg Oncol. Rogasch, J. M. et al. Avigdor A, Bulvik S, Levi I, Dann EJ, Shemtov N, Perez-Avraham G. Engert A, Haverkamp H, Kobe C, Markova J, Renner C, Ho A. Med. 8600 Rockville Pike Sci. Imaging Biol. It is also an expensive and time-consuming procedure, resulting in a high radiation dose for the often young patients9. A 13-valent pneumococcal conjugate vaccine (Prevnar 13), followed by a 23-valent pneumococcal polysaccharide vaccine (Pneumovax 23) at least eight weeks later and then again at least five years later, should be administered following lymphoma treatment. This content is owned by the AAFP. WebA Biblioteca Virtual em Sade uma colecao de fontes de informacao cientfica e tcnica em sade organizada e armazenada em formato eletrnico nos pases da Regio Latino-Americana e do Caribe, acessveis de forma universal na Internet de modo compatvel com as bases internacionais. PET data were acquired from the skull base to the proximal femora in 3D acquisition mode (acquisition time, 23min per bed position). Magn. Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. To achieve reproducible results, we determined the final DS using the qPET approach23. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. The National Comprehensive Cancer Network (NCCN) recommends avoiding certain chemotherapeutic agents in patients older than 60 years. Non-Hodgkin lymphoma is treated with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) with or without rituximab (R-CHOP), bendamustine, and lenalidomide. Slider with three articles shown per slide. Google Scholar. Receiver operating characteristic (ROC) curves were generated, and the area under the ROC curve was calculated to assess the diagnostic accuracy of rPET in detecting a positive response, along with the corresponding cut-off scores. Deauville score versus ratio Deauville score in the interpretation of interim 18F-FDG PET-CT and in prediction of outcome in children with FDG-avid extra-nodal lymphomas. WebRisk stratification on the basis of Deauville score on PET-CT and the presence of Epstein-Barr virus DNA after completion of primary treatment for extranodal natural killer/T-cell lymphomanasal typea multicentreretrospective analysis [J]. 75 PET/CT examinations of 43 patients on two different scanners were included. Ann Oncol 2005;16:1514-23. 2017 May 25;5(5):CD007941. https://doi.org/10.1007/s11307-022-01703-7 (2022). Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. ADS Overall, 26 initial and 49 interim examinations were included. https://doi.org/10.1182/blood-2018-05-852129 (2018). Those with a Deauville score up to 3 were treated with an additional 2 cycles of ABVD whereas those with a positive result received 2 cycles of escalated BEACOPP plus IFRT. The .gov means its official. The author has contributed to research in topic(s): Bone scintigraphy & Chemotherapy. Kwee TC, Kwee RM, Nievelstein RA. Methods: Performance of Philips Gemini TF PET/CT scanner with special consideration for its time-of-flight imaging capabilities. ; Elsafy, U.R. First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. Shammas, A.; Lim, R.; Charron, M. Pediatric FDG PET/CT: Physiologic uptake, normal variants, and benign conditions. ; Kluge, R. FDG PET for therapy monitoring in Hodgkin and non-Hodgkin lymphomas. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. Hodgkin's lymphoma. EJNMMI Phys 7, 2. https://doi.org/10.1186/s40658-020-0270-y (2020). https://CRAN.R-project.org/package=psych. Illustration of ROI placement. Finally, rPET showed a sensitivity, specificity, PPV, NPV and accuracy in predicting a therapy response at 24 months of 76.1%, 100%, 100%, 35.3% and 78.8%, respectively, with a cut-off of 1.31 and an AUC of 0.913 (CI, Hodgkin lymphoma is the third-most-common childhood malignancy. Score 4: Uptake moderately increased compared to the liver at any site, Score 5: Uptake markedly increased compared to the liver at any site, Score X: New areas of uptake unlikely to be related to lymphoma. 2020 Nov 24;4(22):5762-5771. doi: 10.1182/bloodadvances.2020002814. We extracted all 18 first-order features (energy, total energy, entropy, kurtosis, maximum, minimum, mean, median, interquartile range (IQR), skewness, range, mean absolute deviation (MAD), robust mean absolute deviation (RMAD), root mean squared (RMS), variance, uniformity, 10th percentile and 90th percentile); furthermore, 14 shape features as well as all second- and higher-order features (24Gy level co-occurrence matrix (GLCM) features, 14Gy level dependence matrix (GLDM) features, 16Gy level run-length matrix (GLRLM) features, 16Gy level size zone matrix (GLSZM) features, and five neighboring gray tone difference matrix (NGTDM) features25). Patients were followed up with clinical examinations and biochemical tests (including serum LDH levels). International validation study for interim PET in ABVD-treated, advanced-stage Hodgkin lymphoma: Interpretation criteria and concordance rate among reviewers. related lymph node density in Hounsfield units in NECT to malignancy in a broad PET/CT study investigating various malignant entities (lung cancer, malignant melanoma, prostate cancer, gastroenteropancreatic neuroendocrine tumors) using different PET-tracers (18F-FDG, 68Ga-DOTATOC, 68Ga-labeled prostate-specific membrane antigen), but without including patients with Hodgkin's disease39. Search dates: April 18, May 17, and May 31, 2018, and August 30, 2019. Rep. 12, 10192. https://doi.org/10.1038/s41598-022-13967-8 (2022). The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography:[1], Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. Diagnostic value of baseline 18FDG PET/CT skeletal textural features in follicular lymphoma, Comparison of different automatic methods for the delineation of the total metabolic tumor volume in III stage Hodgkin Lymphoma, A PET Radiomics Model to Predict Refractory Mediastinal Hodgkin Lymphoma, Comparison of whole-body MRI, bone scan, and radiographic skeletal survey for lesion detection and risk stratification of Langerhans Cell Histiocytosis, Proposal for a Quantitative 18F-FDG PET/CT Metabolic Parameter to Assess the Intensity of Bone Involvement in Multiple Myeloma, Intensity harmonization techniques influence radiomics features and radiomics-based predictions in sarcoma patients, Investigation of radiomics based intra-patient inter-tumor heterogeneity and the impact of tumor subsampling strategies, Combined whole-lesion radiomic and iodine analysis for differentiation of pulmonary tumors, Radiomics Features Differentiate Between Normal and Tumoral High-Fdg Uptake, https://doi.org/10.1053/j.semnuclmed.2017.09.007, https://doi.org/10.1182/blood-2018-05-852129, https://doi.org/10.1080/10428190903040048, https://doi.org/10.1038/s41598-020-68310-w, https://doi.org/10.1016/j.ymeth.2020.05.022, https://doi.org/10.1038/nrclinonc.2017.141, https://doi.org/10.1016/j.ymeth.2020.06.020, https://doi.org/10.1038/s41598-018-37197-z, https://doi.org/10.1007/s00330-016-4470-8, https://doi.org/10.1097/RLU.0000000000002732, https://doi.org/10.1038/s41598-021-81526-8, https://doi.org/10.1038/s41598-018-31509-z, https://doi.org/10.1186/s40658-019-0244-0, https://doi.org/10.1186/s40658-020-0270-y, https://doi.org/10.1016/j.mri.2012.05.001, https://doi.org/10.1007/s00259-014-2715-9, https://pyradiomics.readthedocs.io/en/latest/features.html, https://doi.org/10.1158/0008-5472.CAN-17-0339, https://doi.org/10.1148/radiol.2020191145, https://doi.org/10.1037//0033-2909.86.2.420, https://doi.org/10.1016/j.softx.2021.100819, https://doi.org/10.1080/10428194.2020.1786555, https://doi.org/10.1148/radiol.2018172361, https://doi.org/10.1007/s00259-021-05233-2, https://doi.org/10.2967/jnumed.116.179648, https://doi.org/10.1007/s11307-017-1155-x, https://doi.org/10.1007/s11307-022-01703-7, https://doi.org/10.1038/s41598-021-03278-9, https://doi.org/10.1038/s41598-022-13967-8, http://creativecommons.org/licenses/by/4.0/.
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