Gardasil | European Medicines Agency But there are also trouble spots, including France, where 1 in 3 people disagree that vaccines are safe, and Ukraine, where only about half of the population thinks that vaccines work. There have also been some reports describing persisting/chronic fatigue, generally with multiple other symptoms (eg, headache, malaise, drowsiness, nausea, gastrointestinal upset, joint swelling, flu-like illness, menstrual disorders) following vaccination.. Multiple countries have paused the use of AstraZeneca's COVID-19 vaccine as a precaution while investigators look into cases of blood clots among vaccinated people. A recent analysis of 4,900 women in Nordic countries, which use more robust medical records systems than the United States, found Gardasil "is effective up to 6 years following vaccination with . Spanish Minister of Health Carolina Darias said Monday that Spain would also suspend the use of the AstraZeneca vaccine for at least 15 days due to concerns about possible side effects. 30 June 2006. If you have a subscription to The BMJ, log in: Subscribe and get access to all BMJ articles, and much more. Credit: Johns Hopkins Medicine. The 9-valent HPV vaccine is efficacious in preventing persistent HPV infection and cervical high-grade or worse lesions caused by the additional HPV types 31, 33, 45, 52 and 58 covered by the vaccine (evidence quality: high) and HPV types 6, 11, 16 and 18 (evidence quality: moderate due to indirectness) in females 16-26 years. It's true that there have been 24,000 reports of adverse events with Gardasil. as well as other partner offers and accept our. The hpv vaccine gardasil is at least 99% effective against the four most odious hpv subtypes in young women. Why has the controversy around the HPV vaccine still not died down? Snopes and the Snopes.com logo are registered service marks of Snopes.com. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low. Access this article for 1 day for:30 / $37 / 33 (excludes VAT). Letter: Dangerous Gardasil drug should be banned in US, A fungus wiped out 3.5 billion American chestnut trees. Please note: your email address is provided to the journal, which may use this information for marketing purposes. "Reports of Health Concerns Following HPV Vaccination." But Dr. Harper also noted that the risks of death surrounding the administration of Gardasil were "very rare," and that she "agrees with Merck and the CDC that Gardasil is safe for most girls and women. The HPV vaccine saves lives, as it can prevent most cervical cancer cases. Prev Med Rep. 2021 Sep 17;24:101562. doi: 10.1016/j.pmedr.2021.101562. Today 6 months after her vaccination, her blood platelets have gone from a low of 100,000 to 132,000 (150,000 to 400,000 is normal). In Ireland, a familiar list of opposition politicians from Sinn Fein to independents have regurgitated the claims verbatim, and speakers from Regret have even been invited to address the Irish parliament. While this makes for an arresting anecdote, the implicit assumption that the temporal sequence is anything other than coincidental is comprehensively debunked by the scientific and statistical evidence against it. Corrected human papillomavirus vaccination rates for each birth fiscal year in Japan. A better approach, Dr. Kobrin went on, would be to say, Lets all talk about why we believe what we believe. Epub 2020 Apr 27. The majority of these infections resolve without symptoms. And based on the data available, it is unlikely (though not impossible) that even those deaths were caused by the vaccine. Gardasil: Introducing the new human papillomavirus vaccine FDA and CDC continue to find that Gardasil is a safe and effective vaccine that will potentially benefit the health of millions of women by providing protection against the types of HPV in the. To learn more about HPV vaccine and the diseases it prevents . Our Standards: The Thomson Reuters Trust Principles. It would continue administering both Pfizer-BioNTech and Moderna's COVID-19 vaccines, it said. The European Commission then decided that the vaccines could continue to be marketed. Find more COVID-19 testing locations on Maryland.gov. 8 March 2007. Only two doses are needed if the first dose was given before 15 th birthday. CDC recommends that 11- to 12-year-olds receive two doses of HPV vaccine 6 to 12 months apart. The CDC and FDA did this for HPV vaccines in 2009, looking at the first 12,424 reports to VAERS and publishing the result in the Journal of the American Medical Association. This slightly twisted assumption is flatly contradicted by the data it operates on a strange, moralistic consequences of sex principle, a mantra that abstinence trumps pragmatism. From 2015 to 2018, more than 39,000 caregivers of teens who had not received the HPV vaccine responded to the survey and selected 1 of 31 reasons for declining the vaccine. It was administered to around 16,000 girls in the district, many of whom stayed in state government-run hostels meant for tribal students. Suspected adverse effects after human papillomavirus vaccination: a temporal relationship. by Elia Ben-Ari, December 22, 2022, Larson HJ, Wilson R, Hanley S, Parys A, Paterson P. Hum Vaccin Immunother. Tradename: GARDASIL 9. AstraZeneca's vaccine has been granted conditional marketing authorization or emergency use in more than 70 countries, including the UK and across the European Union. 2018 Dec;66(6):723-725. doi: 10.1007/s12026-018-9063-y. Sign up for notifications from Insider! There has been a rise in negative and incorrect informationalso called misinformationabout HPV vaccines on social media in recent years, Dr. Sonawane noted. According to CDC and FDA, VAERS data can only be used to find unusual patterns that should be evaluated in additional studies. Germany,. Gardasil has been banned in Japan. The World Health Organization is calling on countries that are vaccinating boys against the human papillomavirus (HPV) to suspend these programmes until all girls who need the vaccine can get it. You cant tell people theyre wrong if you actually want them to hear alternative information. Such skewed coverage also triggers a chorus of populist politicians to chime in with equally vacuous additions. Nor is the vaccine, which has been given to more than 10 million people, likely responsible for those deaths. by Sharon Reynolds, National Cancer Institute For the study, the researchers mined data from the 20102016 National Immunization Survey-Teen (NIS-Teen), a series of annual vaccine monitoring surveys conducted by the U.S. Centers for Disease Control and Prevention. Video: Get the facts, get the HPV vaccine! It's normal for these reports to pour in for safe vaccines. Urgent Warning About Gardasil | Snopes.com Her pediatrician filed a report with the Centers for Disease Control and Prevention about the effects Gardasil had on her; her doctor recommended that she not get the second dose. Gan To Kagaku Ryoho. To look at trends in health issues reported after HPV vaccination, the researchers turned to the Vaccine Adverse Event Reporting System (VAERS), a website operated by CDC and FDA. Over 90% of cervical cancers are caused by HPV. 1995 - 2023 by Snopes Media Group Inc. Stay up to date with what you want to know. We wanted to better understand why parents choose not to vaccinate their children against HPV, since that information is critical for developing improved public health campaigns and provider messages to increase vaccination rates, says study author Anne Rositch, M.S.P.H., Ph.D., assistant professor in the Department of Epidemiology at Johns Hopkins Bloomberg School of Public Health. Unfortunately, VAERS data is notoriously spotty better than nothing, but there's no way to insure that potential side effects are reported. Forbes. And although many of these are harmless, amongst the myriad mutants there are those, which claimed the lives of 270,000 women in 2012, at least 99% effective against the four most odious subtypes, have stagnated far below the optimum levels for protection, the first of which expresses itself as moral concern, advocating abstinence in lieu of vaccination, evidence to date clearly indicates that abstinence programmes simply dont work, sexual activity is not elevated in the vaccinated group, Gardasil has been extensively tested for years, a 2015 report based on data from over a million individuals, success anti-vaccine campaigners have in sharing their claims online, the falsehood that Gardasil has been banned in Japan, Regret claim that upwards of 140 girls are suffering severe non-specific reactions to the vaccination, even been invited to address the Irish parliament, questioned why there was a need for a vaccine. Scientists believe genetically-engineered blight-resistant trees will bring them back, Man smashes window of burning car to rescue woman, 90, after North Adams crash near Walmart, Rescuers save fisherman who fell through the ice on Stockbridge Bowl, A Pittsfield man is sentenced to up to 30 years in prison for attack that seriously injured former girlfriend, If you missed eating BiggDaddy's famous Philly cheesesteaks, you're in luck: BiggDaddy's is reopening, this time in North Adams, Pittsfield police arrest trio at T.J. Maxx for drug possession and dealing, Crews start work on the long-awaited replacement of the Holmes Road bridge in Pittsfield, At about half its capacity for students, Berkshire Country Day School is looking at ways to expand its enrollment, Pittsfield Public schools wonder if handing out Chromebooks to every student is still a good idea, or even worth the cost to taxpayers, Cindy Bartlett has been teaching skiing at Bousquet Mountain Ski Area for 40 years; here's what she wants you to know about learning the sport, Photos: Taconic and Lenox battle in MIAA D-V State Boys Basketball Tournament, Photos: Taconic girls host Hopedale in State Basketball Tournament, Photos: Monument bests Cape Cod Academy in boys state basketball tournament opener, Photos: Literacy Night at Crosby Elementary School aims to teach students that reading brings people together, as part of Read Across America Day, Photos: Pittsfield Basketball State tournament, Photos: Monument Mountain girls vs Fellowship Christian, Photos: State Alpine Ski Championships at Berkshire East, Photos: Man rescued after falling through the ice at Stockbridge Bowl, Photos: Drury girls basketball hosts Innovation Academy in state tournament. Foreign travelers, including family members, friends, and business relations, are being kept off U.S. soil due to the air travel vaccine mandate, which remains for . It protects against two high-risk HPV types (types 16 and 18) and two low-risk types (types 6 and 11). We think all physicians need to be champions of this vaccine that has the potential to prevent tens of thousands of cases of cancers each year, Beavis says. Independent Oversight and Advisory Committee, Major milestone reached as 100 countries have introduced HPV vaccine into national schedule. Before By all measures it has been found to be a safe and effective intervention. Since that licensing the "CDC and FDA have been closely monitoring the safety of the HPV vaccine" and found that: All serious reports for Gardasil have been carefully analyzed by medical experts. Enhertu May Be Preferred Therapy for Some Metastatic Breast Cancers, Adjuvant Immunotherapy Approved for Some Patients with Lung Cancer, If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. Studies on sexual activity in vaccinated and unvaccinated teen cohorts show quite clearly that sexual activity is not elevated in the vaccinated group. A study published in. Gardasil Vaccine Lawsuit | February 2023 Class Action Update The groups attempt to obtain an injunction for a withdrawal of Gardasil made it to the Irish High Court, and although it was refused, the movement shows no signs of abating if anything, they have received an incredibly sympathetic media airing. 'Finally we can protect women': Japan's HPV vaccine battle - France 24 Broadly speaking, opposition can be separated into two distinct categories, the first of which expresses itself as moral concern. Blood work found ITP a rare blood disease that can be fatal. However, HPV is sexually transmitted and can cause genital warts and benign tumors on the aerodigestive tract, a condition called laryngeal papillomatosis. The Latvian health authorities said in a statement that the pause was due to reports of blood clots in people immunized with AstraZeneca's COVID-19 vaccine in other European countries. Even though vaccine hesitancy appears to be rising, there is a subset of people who have misgivingsabout vaccines but are open to changing their minds, Dr. Vanderpool noted. The two companies' respective vaccines the former's Cervarix and the latter's Gardasil were widely marketed as the best available prophylactic, or preventive, for cervical cancer. From June 2006 to March 2013, approximately 57 million doses of HPV vaccines were distributed and VAERS received approximately 22,000 adverse event reports occurring in girls and women who received them. "Around 17 million people in the EU and UK have now received our vaccine, and the number of cases of blood clots reported in this group is lower than the hundreds of cases that would be expected among the general population," Ann Taylor, AstraZeneca's chief medical officer, said. Examining Long-Term Effects of Human Papillomavirus Vaccine Recommendation Messages: A 4-Month Follow-Up Survey of a Randomized Controlled Study in Japan. Everyone else must pay out of pocket. But from 2015 to 2018, the study showed, the percentage of parents who declined the HPV vaccine for their kids due to safety concerns nearly doubled. eCollection 2021 Dec. J Clin Invest. The Guttmacher Institute, which conducts independent research on sexual activity, sexually transmitted diseases and reproductive health, reports that an estimated 50 percent of teens ages 15 to 19 have oral sex with an opposite sex partner and 1 in 10 has anal sex with an opposite sex partner. 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gardasil vaccine banned in what countries

gardasil vaccine banned in what countries

Some countries have responded by pausing all use of AstraZeneca's vaccine pending an EMA investigation, while others said they would just stop use of one batch. sharing sensitive information, make sure youre on a federal 3 May 2012. When autocomplete results are available use up and down arrows to review and enter to select. 2022 Apr 29;10(5):701. doi: 10.3390/vaccines10050701. CBS News. A major concern appears to be that without the fear of genital warts or cervical cancer, young people will become more promiscuous, and that the HPV vaccine therefore in effect encourages behaviour they deem immoral. Gardasil | European Medicines Agency But there are also trouble spots, including France, where 1 in 3 people disagree that vaccines are safe, and Ukraine, where only about half of the population thinks that vaccines work. There have also been some reports describing persisting/chronic fatigue, generally with multiple other symptoms (eg, headache, malaise, drowsiness, nausea, gastrointestinal upset, joint swelling, flu-like illness, menstrual disorders) following vaccination.. Multiple countries have paused the use of AstraZeneca's COVID-19 vaccine as a precaution while investigators look into cases of blood clots among vaccinated people. A recent analysis of 4,900 women in Nordic countries, which use more robust medical records systems than the United States, found Gardasil "is effective up to 6 years following vaccination with . Spanish Minister of Health Carolina Darias said Monday that Spain would also suspend the use of the AstraZeneca vaccine for at least 15 days due to concerns about possible side effects. 30 June 2006. If you have a subscription to The BMJ, log in: Subscribe and get access to all BMJ articles, and much more. Credit: Johns Hopkins Medicine. The 9-valent HPV vaccine is efficacious in preventing persistent HPV infection and cervical high-grade or worse lesions caused by the additional HPV types 31, 33, 45, 52 and 58 covered by the vaccine (evidence quality: high) and HPV types 6, 11, 16 and 18 (evidence quality: moderate due to indirectness) in females 16-26 years. It's true that there have been 24,000 reports of adverse events with Gardasil. as well as other partner offers and accept our. The hpv vaccine gardasil is at least 99% effective against the four most odious hpv subtypes in young women. Why has the controversy around the HPV vaccine still not died down? Snopes and the Snopes.com logo are registered service marks of Snopes.com. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low. Access this article for 1 day for:30 / $37 / 33 (excludes VAT). Letter: Dangerous Gardasil drug should be banned in US, A fungus wiped out 3.5 billion American chestnut trees. Please note: your email address is provided to the journal, which may use this information for marketing purposes. "Reports of Health Concerns Following HPV Vaccination." But Dr. Harper also noted that the risks of death surrounding the administration of Gardasil were "very rare," and that she "agrees with Merck and the CDC that Gardasil is safe for most girls and women. The HPV vaccine saves lives, as it can prevent most cervical cancer cases. Prev Med Rep. 2021 Sep 17;24:101562. doi: 10.1016/j.pmedr.2021.101562. Today 6 months after her vaccination, her blood platelets have gone from a low of 100,000 to 132,000 (150,000 to 400,000 is normal). In Ireland, a familiar list of opposition politicians from Sinn Fein to independents have regurgitated the claims verbatim, and speakers from Regret have even been invited to address the Irish parliament. While this makes for an arresting anecdote, the implicit assumption that the temporal sequence is anything other than coincidental is comprehensively debunked by the scientific and statistical evidence against it. Corrected human papillomavirus vaccination rates for each birth fiscal year in Japan. A better approach, Dr. Kobrin went on, would be to say, Lets all talk about why we believe what we believe. Epub 2020 Apr 27. The majority of these infections resolve without symptoms. And based on the data available, it is unlikely (though not impossible) that even those deaths were caused by the vaccine. Gardasil: Introducing the new human papillomavirus vaccine FDA and CDC continue to find that Gardasil is a safe and effective vaccine that will potentially benefit the health of millions of women by providing protection against the types of HPV in the. To learn more about HPV vaccine and the diseases it prevents . Our Standards: The Thomson Reuters Trust Principles. It would continue administering both Pfizer-BioNTech and Moderna's COVID-19 vaccines, it said. The European Commission then decided that the vaccines could continue to be marketed. Find more COVID-19 testing locations on Maryland.gov. 8 March 2007. Only two doses are needed if the first dose was given before 15 th birthday. CDC recommends that 11- to 12-year-olds receive two doses of HPV vaccine 6 to 12 months apart. The CDC and FDA did this for HPV vaccines in 2009, looking at the first 12,424 reports to VAERS and publishing the result in the Journal of the American Medical Association. This slightly twisted assumption is flatly contradicted by the data it operates on a strange, moralistic consequences of sex principle, a mantra that abstinence trumps pragmatism. From 2015 to 2018, more than 39,000 caregivers of teens who had not received the HPV vaccine responded to the survey and selected 1 of 31 reasons for declining the vaccine. It was administered to around 16,000 girls in the district, many of whom stayed in state government-run hostels meant for tribal students. Suspected adverse effects after human papillomavirus vaccination: a temporal relationship. by Elia Ben-Ari, December 22, 2022, Larson HJ, Wilson R, Hanley S, Parys A, Paterson P. Hum Vaccin Immunother. Tradename: GARDASIL 9. AstraZeneca's vaccine has been granted conditional marketing authorization or emergency use in more than 70 countries, including the UK and across the European Union. 2018 Dec;66(6):723-725. doi: 10.1007/s12026-018-9063-y. Sign up for notifications from Insider! There has been a rise in negative and incorrect informationalso called misinformationabout HPV vaccines on social media in recent years, Dr. Sonawane noted. According to CDC and FDA, VAERS data can only be used to find unusual patterns that should be evaluated in additional studies. Germany,. Gardasil has been banned in Japan. The World Health Organization is calling on countries that are vaccinating boys against the human papillomavirus (HPV) to suspend these programmes until all girls who need the vaccine can get it. You cant tell people theyre wrong if you actually want them to hear alternative information. Such skewed coverage also triggers a chorus of populist politicians to chime in with equally vacuous additions. Nor is the vaccine, which has been given to more than 10 million people, likely responsible for those deaths. by Sharon Reynolds, National Cancer Institute For the study, the researchers mined data from the 20102016 National Immunization Survey-Teen (NIS-Teen), a series of annual vaccine monitoring surveys conducted by the U.S. Centers for Disease Control and Prevention. Video: Get the facts, get the HPV vaccine! It's normal for these reports to pour in for safe vaccines. Urgent Warning About Gardasil | Snopes.com Her pediatrician filed a report with the Centers for Disease Control and Prevention about the effects Gardasil had on her; her doctor recommended that she not get the second dose. Gan To Kagaku Ryoho. To look at trends in health issues reported after HPV vaccination, the researchers turned to the Vaccine Adverse Event Reporting System (VAERS), a website operated by CDC and FDA. Over 90% of cervical cancers are caused by HPV. 1995 - 2023 by Snopes Media Group Inc. Stay up to date with what you want to know. We wanted to better understand why parents choose not to vaccinate their children against HPV, since that information is critical for developing improved public health campaigns and provider messages to increase vaccination rates, says study author Anne Rositch, M.S.P.H., Ph.D., assistant professor in the Department of Epidemiology at Johns Hopkins Bloomberg School of Public Health. Unfortunately, VAERS data is notoriously spotty better than nothing, but there's no way to insure that potential side effects are reported. Forbes. And although many of these are harmless, amongst the myriad mutants there are those, which claimed the lives of 270,000 women in 2012, at least 99% effective against the four most odious subtypes, have stagnated far below the optimum levels for protection, the first of which expresses itself as moral concern, advocating abstinence in lieu of vaccination, evidence to date clearly indicates that abstinence programmes simply dont work, sexual activity is not elevated in the vaccinated group, Gardasil has been extensively tested for years, a 2015 report based on data from over a million individuals, success anti-vaccine campaigners have in sharing their claims online, the falsehood that Gardasil has been banned in Japan, Regret claim that upwards of 140 girls are suffering severe non-specific reactions to the vaccination, even been invited to address the Irish parliament, questioned why there was a need for a vaccine. Scientists believe genetically-engineered blight-resistant trees will bring them back, Man smashes window of burning car to rescue woman, 90, after North Adams crash near Walmart, Rescuers save fisherman who fell through the ice on Stockbridge Bowl, A Pittsfield man is sentenced to up to 30 years in prison for attack that seriously injured former girlfriend, If you missed eating BiggDaddy's famous Philly cheesesteaks, you're in luck: BiggDaddy's is reopening, this time in North Adams, Pittsfield police arrest trio at T.J. Maxx for drug possession and dealing, Crews start work on the long-awaited replacement of the Holmes Road bridge in Pittsfield, At about half its capacity for students, Berkshire Country Day School is looking at ways to expand its enrollment, Pittsfield Public schools wonder if handing out Chromebooks to every student is still a good idea, or even worth the cost to taxpayers, Cindy Bartlett has been teaching skiing at Bousquet Mountain Ski Area for 40 years; here's what she wants you to know about learning the sport, Photos: Taconic and Lenox battle in MIAA D-V State Boys Basketball Tournament, Photos: Taconic girls host Hopedale in State Basketball Tournament, Photos: Monument bests Cape Cod Academy in boys state basketball tournament opener, Photos: Literacy Night at Crosby Elementary School aims to teach students that reading brings people together, as part of Read Across America Day, Photos: Pittsfield Basketball State tournament, Photos: Monument Mountain girls vs Fellowship Christian, Photos: State Alpine Ski Championships at Berkshire East, Photos: Man rescued after falling through the ice at Stockbridge Bowl, Photos: Drury girls basketball hosts Innovation Academy in state tournament. Foreign travelers, including family members, friends, and business relations, are being kept off U.S. soil due to the air travel vaccine mandate, which remains for . It protects against two high-risk HPV types (types 16 and 18) and two low-risk types (types 6 and 11). We think all physicians need to be champions of this vaccine that has the potential to prevent tens of thousands of cases of cancers each year, Beavis says. Independent Oversight and Advisory Committee, Major milestone reached as 100 countries have introduced HPV vaccine into national schedule. Before By all measures it has been found to be a safe and effective intervention. Since that licensing the "CDC and FDA have been closely monitoring the safety of the HPV vaccine" and found that: All serious reports for Gardasil have been carefully analyzed by medical experts. Enhertu May Be Preferred Therapy for Some Metastatic Breast Cancers, Adjuvant Immunotherapy Approved for Some Patients with Lung Cancer, If you would like to reproduce some or all of this content, see Reuse of NCI Information for guidance about copyright and permissions. Studies on sexual activity in vaccinated and unvaccinated teen cohorts show quite clearly that sexual activity is not elevated in the vaccinated group. A study published in. Gardasil Vaccine Lawsuit | February 2023 Class Action Update The groups attempt to obtain an injunction for a withdrawal of Gardasil made it to the Irish High Court, and although it was refused, the movement shows no signs of abating if anything, they have received an incredibly sympathetic media airing. 'Finally we can protect women': Japan's HPV vaccine battle - France 24 Broadly speaking, opposition can be separated into two distinct categories, the first of which expresses itself as moral concern. Blood work found ITP a rare blood disease that can be fatal. However, HPV is sexually transmitted and can cause genital warts and benign tumors on the aerodigestive tract, a condition called laryngeal papillomatosis. The Latvian health authorities said in a statement that the pause was due to reports of blood clots in people immunized with AstraZeneca's COVID-19 vaccine in other European countries. Even though vaccine hesitancy appears to be rising, there is a subset of people who have misgivingsabout vaccines but are open to changing their minds, Dr. Vanderpool noted. The two companies' respective vaccines the former's Cervarix and the latter's Gardasil were widely marketed as the best available prophylactic, or preventive, for cervical cancer. From June 2006 to March 2013, approximately 57 million doses of HPV vaccines were distributed and VAERS received approximately 22,000 adverse event reports occurring in girls and women who received them. "Around 17 million people in the EU and UK have now received our vaccine, and the number of cases of blood clots reported in this group is lower than the hundreds of cases that would be expected among the general population," Ann Taylor, AstraZeneca's chief medical officer, said. Examining Long-Term Effects of Human Papillomavirus Vaccine Recommendation Messages: A 4-Month Follow-Up Survey of a Randomized Controlled Study in Japan. Everyone else must pay out of pocket. But from 2015 to 2018, the study showed, the percentage of parents who declined the HPV vaccine for their kids due to safety concerns nearly doubled. eCollection 2021 Dec. J Clin Invest. The Guttmacher Institute, which conducts independent research on sexual activity, sexually transmitted diseases and reproductive health, reports that an estimated 50 percent of teens ages 15 to 19 have oral sex with an opposite sex partner and 1 in 10 has anal sex with an opposite sex partner.

I Have A Dream Commonlit Answer Key Pdf, Lake County Mugshots 2021, 5ive Rapper Twin Brother Death, Articles G